本帖最后由 studio23 于 2011-9-4 22:19 编辑
不太喜欢这种标题党。
http://blog.sina.com.cn/s/blog_4bb17e9d0100lrox.html
原文可能是这个
[41]“转基因玉米喂养老鼠新的研究分析显示大鼠肝肾毒性迹象”，环境污染毒理学杂志，52（4）：596-602，作者：Séralini GE, Cellier D, de Vendomois JS，2007年5月
感兴趣的可以找来看看原文，再看看引用。最好是有多个课题组得到比较一致的结论，再做定论。
先贴个原文摘要。
被引38次
New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity
Séralini, G.-E.a b   , Cellier, D.a c , De Vendomois, J.S.a  a Committee for Independent Information and Research on Genetic Engineering CRIIGEN, Paris, France
b Laboratory of Biochemistry, Institute of Biology, University of Caen, Caen, France
c Laboratory LITIS, University of Rouen, Mont-Saint-Aignan, France
Abstract Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological findings, and the results remained controversial. An Appeal Court action in Germany (Münster) allowed public access in June 2005 to all the crude data from this 90-day rat-feeding study. We independently re-analyzed these data. Appropriate statistics were added, such as a multivariate analysis of the growth curves, and for biochemical parameters comparisons between GMO-treated rats and the controls fed with an equivalent normal diet, and separately with six reference diets with different compositions. We observed that after the consumption of MON863, rats showed slight but dose-related significant variations in growth for both sexes, resulting in 3.3% decrease in weight for males and 3.7% increase for females. Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24-40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31-35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested. Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product. © 2007 Springer Science+Business Media, LLC.
再贴个随后立即的引用，被引15次
Food and Chemical Toxicology
Volume 45, Issue 11, November 2007, Pages 2073-2085
Report of an Expert Panel on the reanalysis by Séralini et al. (2007) of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863)
Doull, J.a , Gaylor, D.b , Greim, H.A.c , Lovell, D.P.d , Lynch, B.e , Munro, I.C.e a Pharmacology, Toxicology and Therapeutics, Division of Toxicology, Department of Pharmacology, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7417, United States
b Gaylor and Associates, LLC, 453 County Road 212, Eureka Springs, AR 72631, United States
c Institute of Toxicology and Environmental Hygiene, Technical University of Munich, Hohenbachernsrasse 15-17, D-85354 Freising Weihenstephan, Germany
d Postgraduate Medical School, University of Surrey, Daphne Jackson Road, Manor Park, Guildford, GU2 7WG, United Kingdom
e Cantox Health Sciences, Inc., Suite 308, 2233 Argentia Road, Mississauga, Ont. L5N 2X7, Canada
Abstract MON 863, a genetically engineered corn variety that contains the gene for modified Bacillus thuringiensis Cry3Bb1 protein to protect against corn rootworm, was tested in a 90-day toxicity study as part of the process to gain regulatory approval. This study was reanalyzed by Séralini et al. who contended that the study showed possible hepatorenal effects of MON 863. An Expert Panel was convened to assess the original study results as analyzed by the Monsanto Company and the reanalysis conducted by Séralini et al. The Expert Panel concludes that the Séralini et al. reanalysis provided no evidence to indicate that MON 863 was associated with adverse effects in the 90-day rat study. In each case, statistical findings reported by both Monsanto and Séralini et al. were considered to be unrelated to treatment or of no biological or clinical importance because they failed to demonstrate a dose-response relationship, reproducibility over time, association with other relevant changes (e.g., histopathology), occurrence in both sexes, difference outside the normal range of variation, or biological plausibility with respect to cause-and-effect. The Séralini et al. reanalysis does not advance any new scientific data to indicate that MON 863 caused adverse effects in the 90-day rat study. © 2007 Elsevier Ltd. All rights reserved.
再贴一个，被引8次
Histochemistry and Cell Biology
Volume 130, Issue 5, November 2008, Pages 967-977
A long-term study on female mice fed on a genetically modified soybean: Effects on liver ageing
Malatesta, M.a , Boraldi, F.b , Annovi, G.b , Baldelli, B.c , Battistelli, S.c , Biggiogera, M.d , Quaglino, D.b a Dipartimento di Scienze Morfologico-Biomediche, Sezione di Anatomia e Istologia, University of Verona, strada Le Grazie 8, Verona 37134, Italy
b Department of Biomedical Sciences, University of Modena e Reggio Emilia, Modena 41100, Italy
c Istituto di Istologia e Analisi di Laboratorio, University of Urbino, Urbino (PU) 61029, Italy
d Dipartimento di Biologia Animale, Laboratorio di Biologia Cellulare e Neurobiologia, University of Pavia, Pavia 27100, Italy
Abstract Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions. © 2008 Springer-Verlag.
最后是该法国课题组最近的一篇，被引14次
A comparison of the effects of three GM corn varieties on mammalian health
a CRIIGEN, 40 rue Monceau, 75008 Paris, France
b University of Rouen LITIS EA 4108, 76821 Mont-Saint-Aignan, France
c Institute of Biology, University of Caen, Risk Pole CNRS, EA 2608, 14032 Caen, France
Abstract We present for the first time a comparative analysis of blood and organ system data from trials with rats fed three main commercialized genetically modified (GM) maize (NK 603, MON 810, MON 863), which are present in food and feed in the world. NK 603 has been modified to be tolerant to the broad spectrum herbicide Roundup and thus contains residues of this formulation. MON 810 and MON 863 are engineered to synthesize two different Bt toxins used as insecticides. Approximately 60 different biochemical parameters were classified per organ and measured in serum and urine after 5 and 14 weeks of feeding. GM maize-fed rats were compared first to their respective isogenic or parental non-GM equivalent control groups. This was followed by comparison to six reference groups, which had consumed various other non-GM maize varieties. We applied nonparametric methods, including multiple pairwise comparisons with a False Discovery Rate approach. Principal Component Analysis allowed the investigation of scattering of different factors (sex, weeks of feeding, diet, dose and group). Our analysis clearly reveals for the 3 GMOs new side effects linked with GM maize consumption, which were sex- and often dose-dependent. Effects were mostly associated with the kidney and liver, the dietary detoxifying organs, although different between the 3 GMOs. Other effects were also noticed in the heart, adrenal glands, spleen and haematopoietic system. We conclude that these data highlight signs of hepatorenal toxicity, possibly due to the new pesticides specific to each GM corn. In addition, unintended direct or indirect metabolic consequences of the genetic modification cannot be excluded. © Ivyspring International Publisher.
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